{"id":64,"date":"2024-06-23T23:54:55","date_gmt":"2024-06-23T16:54:55","guid":{"rendered":"https:\/\/diadanhkhmer.wordpress.com\/?p=64"},"modified":"2024-06-23T23:54:55","modified_gmt":"2024-06-23T16:54:55","slug":"go-quao","status":"publish","type":"post","link":"https:\/\/wiki.nguoianphu.com\/diadanh\/2024\/06\/23\/go-quao\/","title":{"rendered":"G\u00f2 Quao"},"content":{"rendered":"\n<p>G\u00f2 Quao l\u00e0 m\u1ed9t huy\u1ec7n thu\u1ed9c t\u1ec9nh Ki\u00ean Giang.<br><a href=\"https:\/\/vi.wikipedia.org\/wiki\/G%C3%B2_Quao\">https:\/\/vi.wikipedia.org\/wiki\/G%C3%B2_Quao<\/a><\/p>\n\n\n\n<p>Theo&nbsp;<a class=\"\" href=\"http:\/\/www.nguoianphu.com\/topic\/22\/dia-danh-tam-phong-long\/2#post-90\">L\u00ea Trung Hoa<\/a>:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>G\u00f2 Quao l\u00e0 huy\u1ec7n c\u1ee7a t\u1ec9nh Ki\u00ean Giang, di\u1ec7n t\u00edch 424,3km2, d\u00e2n s\u1ed1134.400 ng\u01b0\u1eddi (2006), g\u1ed3m m\u1ed9t th\u1ecb tr\u1ea5n v\u00e0 10 x\u00e3. G\u00f2 Quao v\u1ed1n c\u00f3 ngh\u0129a l\u00e0 \u201cg\u00f2 c\u00f3 nhi\u1ec1u c\u00e2y quao\u201d. Quao l\u00e0 \u201cgi\u1ed1ng c\u00e2y l\u00e1 c\u00f3 ch\u1ea5t nhu\u1ed9m m\u00e0u \u0111en\u201d.*<\/p>\n<\/blockquote>\n\n\n\n<p>Trong khi \u0111\u00f3, ti\u1ebfng Khmer g\u1ecdi G\u00f2 Quao l\u00e0 \u17a2\u17c6\u1796\u17b6\u1785\u179c\u17c2\u1784 \/\u00c2mp\u00e9ach V\u00eang\/ l\u00e0 m\u01b0\u01a1ng n\u01b0\u1edbc d\u00e0i ho\u1eb7c c\u1ed1ng d\u00e0i.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u17a2\u17c6\u1796\u17b6\u1785 ( n ) [\u0294\u0251mpiec] : m\u01b0\u01a1ng, c\u1ed1ng, r\u00e3nh n\u01b0\u1edbc<\/li>\n\n\n\n<li>\u179c\u17c2\u1784 ( adj ) [v\u025b\u025b\u014b] : d\u00e0i, cao<\/li>\n<\/ul>\n\n\n\n<p>\u1796\u17d2\u179a\u17c3\u179c\u17c2\u1784 Prey Veng \/<strong>IPA<\/strong>: \/preyv\u025b\u025b\u014b\/\/: t\u1ec9nh Prey Veng, \u1796\u17d2\u179a\u17c3\u00a0r\u1eebng \u179c\u17c2\u1784 d\u00e0i<\/p>\n\n\n\n<!--more-->\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/acacia-ae.com\/wp-content\/uploads\/2020\/03\/Dolichandrone-spathacea.jpg\" alt=\"\" \/><figcaption class=\"wp-element-caption\">Dolichandrone spathacea<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-acacia-llc wp-block-embed-acacia-llc\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"xOlmMvXMNR\"><a href=\"https:\/\/acacia-ae.com\/product\/dolichandrone-spathacea\/\">Dolichandrone spathacea<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Dolichandrone spathacea&#8221; &#8212; Acacia LLC\" src=\"https:\/\/acacia-ae.com\/product\/dolichandrone-spathacea\/embed\/#?secret=uH4dJ6C0Mq#?secret=xOlmMvXMNR\" data-secret=\"xOlmMvXMNR\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p>https:\/\/vast.gov.vn\/web\/guest\/tin-chi-tiet\/-\/chi-tiet\/nghien-cuu-quy-trinh-chiet-xuat-cac-hop-chat-iridoid-tu-cay-quao-nuoc-dolichandrone-spathacea-va-tong-hop-mot-so-dan-xuat-%C4%91e-tao-che-pham-ha-%C4%91uong-huyet-47850-2.html<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Nghi\u00ean c\u1ee9u quy tr\u00ecnh chi\u1ebft xu\u1ea5t c\u00e1c h\u1ee3p ch\u1ea5t iridoid t\u1eeb c\u00e2y Quao n\u01b0\u1edbc (Dolichandrone spathacea) v\u00e0 t\u1ed5ng h\u1ee3p m\u1ed9t s\u1ed1 d\u1eabn xu\u1ea5t \u0111\u1ec3 t\u1ea1o ch\u1ebf ph\u1ea9m h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft<\/h1>\n\n\n\n<p>08\/07\/2022<\/p>\n\n\n\n<p>B\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng hay c\u00f2n g\u1ecdi l\u00e0 b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng l\u00e0 m\u1ed9t d\u1ea1ng b\u1ec7nh n\u1ed9i ti\u1ebft do r\u1ed1i lo\u1ea1n chuy\u1ec3n h\u00f3a cacbohydrat khi h\u00f3c m\u00f4n insulin c\u1ee7a t\u1ee5y b\u1ecb thi\u1ebfu hay gi\u1ea3m t\u00e1c \u0111\u1ed9ng trong c\u01a1 th\u1ec3. Theo t\u1ed5 ch\u1ee9c Y t\u1ebf th\u1ebf gi\u1edbi v\u00e0 Li\u00ean \u0111o\u00e0n \u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng, Vi\u1ec7t Nam l\u00e0 m\u1ed9t trong nh\u1eefng n\u01b0\u1edbc c\u00f3 t\u1ef7 l\u1ec7 gia t\u0103ng b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng nhanh nh\u1ea5t th\u1ebf gi\u1edbi. Hi\u1ec7n nay, xu h\u01b0\u1edbng ki\u1ec3m so\u00e1t b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng \u0111ang chuy\u1ec3n d\u1ecbch t\u1eeb \u0111i\u1ec1u tr\u1ecb b\u1eb1ng t\u00e2y y sang k\u1ebft h\u1ee3p thu\u1ed1c t\u00e2y \u0111i\u1ec1u tr\u1ecb v\u1edbi s\u1eed d\u1ee5ng th\u1ea3o d\u01b0\u1ee3c c\u00f3 ngu\u1ed3n g\u1ed1c thi\u00ean nhi\u00ean, v\u1eeba n\u00e2ng cao \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 h\u1ea1 v\u00e0 \u1ed5n \u0111\u1ecbnh \u0111\u01b0\u1eddng huy\u1ebft, v\u1eeba gi\u00fap gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c. \u0110\u00f3ng g\u00f3p nghi\u00ean c\u1ee9u trong l\u0129nh v\u1ef1c n\u00e0y, PGS.TS. Tr\u1ea7n Th\u1ecb Ph\u01b0\u01a1ng Th\u1ea3o v\u00e0 nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a Vi\u1ec7n H\u00f3a h\u1ecdc \u0111\u00e3 ti\u1ebfn h\u00e0nh \u0111\u1ec1 t\u00e0i : Nghi\u00ean c\u1ee9u quy tr\u00ecnh chi\u1ebft xu\u1ea5t c\u00e1c h\u1ee3p ch\u1ea5t irinoid t\u1eeb c\u00e2y Quao n\u01b0\u1edbc (Dolichandrone spathacea) v\u00e0 t\u1ed5ng h\u1ee3p m\u1ed9t s\u1ed1 d\u1eabn xu\u1ea5t \u0111\u1ec3 t\u1ea1o ch\u1ebf ph\u1ea9m h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, m\u00e3 s\u1ed1: VAST04.03\/19-20.<\/p>\n\n\n\n<p>M\u1ee5c ti\u00eau nghi\u00ean c\u1ee9u l\u00e0 \u0111\u01b0a ra \u0111\u01b0\u1ee3c quy tr\u00ecnh chi\u1ebft xu\u1ea5t c\u00e1c h\u1ee3p ch\u1ea5t irinoid t\u1eeb c\u00e2y Quao n\u01b0\u1edbc v\u1edbi hi\u1ec7u su\u1ea5t cao, \u0111\u01b0a ra quy tr\u00ecnh chuy\u1ec3n h\u00f3a t\u1ea1o c\u00e1c d\u1eabn xu\u1ea5t c\u1ee7a c\u00e1c irinoid chi\u1ebft t\u00e1ch \u0111\u01b0\u1ee3c, \u0111\u1ed3ng th\u1eddi t\u1ea1o \u0111\u01b0\u1ee3c ch\u1ebf ph\u1ea9m ch\u1ee9a irinoid c\u00f3 t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft t\u1ed1t.<\/p>\n\n\n\n<p>Quao n\u01b0\u1edbc l\u00e0 m\u1ed9t lo\u00e0i c\u00e2y ng\u1eadp m\u1eb7n c\u00f3 t\u00ean khoa h\u1ecdc l\u00e0&nbsp;<em>Dolichandrone spathacea<\/em>&nbsp;(L.f) K. Schum. thu\u1ed9c h\u1ecd Quao (Bignoniacea): C\u00e2y m\u1ecdc \u1edf nhi\u1ec1u n\u01a1i tr\u00ean th\u1ebf gi\u1edbi, trong \u0111\u00f3 c\u00f3 Vi\u1ec7t Nam. V\u1ec1 th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc, c\u00e1c h\u1ee3p ch\u1ea5t ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c t\u1eeb lo\u00e0i Quao n\u01b0\u1edbc ch\u1ee7 y\u1ebfu thu\u1ed9c nh\u00f3m iridoid. \u1ede v\u00f9ng Nam b\u1ed9 n\u01b0\u1edbc ta, \u0111\u1eb7c bi\u1ec7t \u1edf v\u00f9ng \u0111\u1ed3ng b\u1eb1ng s\u00f4ng C\u1eedu Long, lo\u00e0i Quao n\u01b0\u1edbc r\u1ea5t ph\u1ed5 bi\u1ebfn. C\u00e2y m\u1ecdc tr\u00ean b\u00f9n, d\u1ef1a r\u1ea1ch c\u00f3 tri\u1ec1u v\u00e0 r\u1eebng s\u00e1c, sau r\u1eebng s\u00fa v\u1eb9t v\u00e0 d\u1ecdc c\u00e1c c\u1eeda s\u00f4ng, th\u01b0\u1eddng c\u00f3 d\u1ea1ng c\u00e2y b\u1ee5i v\u00e0 c\u00f3 khi c\u0169ng g\u1eb7p \u1edf nh\u1eefng n\u01a1i g\u1ea7n b\u00e3i bi\u1ec3n. \u1ede v\u00f9ng sau s\u00fa v\u1eb9t th\u01b0\u1eddng l\u00e0 c\u00e2y g\u1ed7, c\u00f3 khi ch\u1ec9 mang l\u00e1 trong m\u1ed9t th\u1eddi gian ng\u1eafn (v\u00e0o m\u00f9a kh\u00f4), c\u0169ng c\u00f3 l\u00fac c\u00e2y c\u00f3 l\u00e1 v\u00e0 hoa quanh n\u0103m. Trong \u0111\u1eddi s\u1ed1ng, c\u00e2y Quao c\u00f3 nhi\u1ec1u c\u00f4ng d\u1ee5ng nh\u01b0 l\u00e0m thu\u1ed1c nhu\u1eadn gan, thu\u1ed1c ti\u00eau \u0111\u1ed9c, ch\u1eefa d\u1ecb \u1ee9ng, kh\u1eed tr\u00f9ng. Hoa v\u00e0 tr\u00e1i non c\u1ee7a c\u00e2y Quao \u0103n \u0111\u01b0\u1ee3c.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.1.png\/018dd35e-936e-499d-8c07-e5078dedd51c?t=1657266214409\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.1.png\/018dd35e-936e-499d-8c07-e5078dedd51c?t=1657266214409\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.2.png\/ab005191-ef22-41ec-8033-def9444a31d4?t=1657266217564\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.2.png\/ab005191-ef22-41ec-8033-def9444a31d4?t=1657266217564\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.3.png\/8864b9a2-6caf-445e-8c14-c14dc9ff7e82?t=1657266220039\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.3.png\/8864b9a2-6caf-445e-8c14-c14dc9ff7e82?t=1657266220039\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<p><em>Qu\u1ea3, l\u00e1 v\u00e0 hoa c\u1ee7a c\u00e2y Quao n\u01b0\u1edbc (Dolichandrone spathacea)<\/em><\/p>\n\n\n\n<p>Iridoid l\u00e0 c\u00e1c h\u1ee3p ch\u1ea5t th\u1ee9 c\u1ea5p \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong nhi\u1ec1u lo\u00e0i th\u1ef1c v\u1eadt v\u00e0 m\u1ed9t s\u1ed1 \u0111\u1ed9ng v\u1eadt. Ch\u00fang l\u00e0 c\u00e1c monoterpen \u0111\u01b0\u1ee3c sinh t\u1ed5ng h\u1ee3p t\u1eeb isopren v\u00e0 th\u01b0\u1eddng l\u00e0 ch\u1ea5t trung gian trong qu\u00e1 tr\u00ecnh sinh t\u1ed5ng h\u1ee3p alkaloid. V\u1ec1 c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc, iridoid th\u01b0\u1eddng c\u00f3 m\u1ed9t v\u00f2ng cyclopentan \u0111\u01b0\u1ee3c n\u1ed1i v\u1edbi 1 v\u00f2ng d\u1ecb t\u1ed1 6 c\u1ea1nh ch\u1ee9a oxi. C\u00e1c h\u1ee3p ch\u1ea5t iridoid th\u01b0\u1eddng c\u00f3 nhi\u1ec1u ho\u1ea1t t\u00ednh th\u00fa v\u1ecb nh\u01b0 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, gi\u1ea3m \u0111au, ch\u1ed1ng vi\u00eam, ch\u1ed1ng co th\u1eaft, ch\u1ed1ng s\u01b0ng t\u1ea5y, ch\u1ed1ng virus, nhu\u1eadn tr\u00e0ng. \u0110\u1eb7c bi\u1ec7t, trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, ho\u1ea1t t\u00ednh h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a c\u00e1c iridoid \u0111\u01b0\u1ee3c c\u00e1c nh\u00e0 khoa h\u1ecdc tr\u00ean th\u1ebf gi\u1edbi quan t\u00e2m nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n<p>C\u00e1c iridoid c\u00f3 ho\u1ea1t t\u00ednh h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft m\u1ea1nh. V\u00ec v\u1eady, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u0103m d\u00f2 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf enzyme \u03b1-glucosidase c\u1ee7a hai iridoid&nbsp;<strong>QN1&nbsp;<\/strong>v\u00e0&nbsp;<strong>QN2<\/strong>. K\u1ebft qu\u1ea3 cho th\u1ea5y hai h\u1ee3p ch\u1ea5t n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf enzyme \u03b1- glucosidase t\u1ed1t h\u01a1n acarbose v\u1edbi IC50 l\u1ea7n l\u01b0\u1ee3t l\u00e0 191.50 v\u00e0 175.52 \u03bcM (ch\u1ea5t \u0111\u1ed1i ch\u1ee9ng acarbose 278.80 \u03bcM). C\u00e1c nghi\u00ean c\u1ee9u c\u1ee7a nh\u00f3m \u0111\u00e3 cho th\u1ea5y l\u1edbp ch\u1ea5t iridoid chi\u1ebfm h\u00e0m l\u01b0\u1ee3ng l\u1edbn trong c\u00e2y \u1edf c\u1ea3 v\u1ecf, c\u00e0nh v\u00e0 l\u00e1 Quao n\u01b0\u1edbc. Tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh chi\u1ebft xu\u1ea5t iridoid quy m\u00f4 ph\u00f2ng th\u00ed nghi\u1ec7m, dung m\u00f4i acetone \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn \u0111\u1ec3 l\u00e0m dung m\u00f4i chi\u1ebft cho quy tr\u00ecnh t\u1ea1o ch\u1ebf ph\u1ea9m quy m\u00f4 100g\/m\u1ebb. Acetone c\u00f3 kh\u1ea3 n\u0103ng chi\u1ebft ch\u1ecdn l\u1ecdc c\u00e1c iridoid, \u00edt \u0111\u1ed9c h\u1ea1i, d\u1ec5 lo\u1ea1i b\u1ecf trong qu\u00e1 tr\u00ecnh chi\u1ebft.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.4.png\/967a5cb0-5fa3-4660-b1fe-4de53e1ac4c9?t=1657266222851\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.4.png\/967a5cb0-5fa3-4660-b1fe-4de53e1ac4c9?t=1657266222851\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<p><em>M\u1ed9t s\u1ed1 h\u1ee3p ch\u1ea5t iridoid ph\u00e2n l\u1eadp t\u1eeb c\u00e2y Quao n\u01b0\u1edbc<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.5.png\/dbeac393-c8fc-45c5-9f84-c3a4772df21a?t=1657266225875\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.5.png\/dbeac393-c8fc-45c5-9f84-c3a4772df21a?t=1657266225875\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<p><em>Quy tr\u00ecnh t\u1ea1o ch\u1ebf ph\u1ea9m Quao n\u01b0\u1edbc quy m\u00f4 100g ch\u1ebf ph\u1ea9m \/ m\u1ebb<\/em><\/p>\n\n\n\n<p>K\u1ebft qu\u1ea3 \u0111\u00e1nh gi\u00e1 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf enzyme \u03b1- glucosidase c\u1ee7a 14 d\u1eabn xu\u1ea5t iridoid cho th\u1ea5y c\u00f3 5 h\u1ee3p ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh cao nh\u1ea5t theo th\u1ee9 t\u1ef1 l\u1ea7n l\u01b0\u1ee3t l\u00e0&nbsp;<strong>QN3&nbsp;<\/strong>\u02c3&nbsp;<strong>QN2&nbsp;<\/strong>\u02c3&nbsp;<strong>QN5&nbsp;<\/strong>\u02c3&nbsp;<strong>QN4&nbsp;<\/strong>\u02c3&nbsp;<strong>QN1&nbsp;<\/strong>(t\u01b0\u01a1ng \u1ee9ng v\u1edbi c\u00e1c gi\u00e1 tr\u1ecb IC50 0,05; 7,24; 8,65; 20,84 v\u00e0 24,89 \u03bcM, ch\u1ea5t \u0111\u1ed1i ch\u1ee9ng acarbose IC50 285,0 \u03bcM). H\u1ee3p ch\u1ea5t QN3 (nemoroside) th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf enzyme \u03b1-glucosidase ti\u1ec1m n\u0103ng nh\u1ea5t, m\u1ea1nh g\u1ea5p 5700 l\u1ea7n ch\u1ea5t \u0111\u1ed1i ch\u1ee9ng. Nghi\u00ean c\u1ee9u docking ph\u00e2n t\u1eed cho k\u1ebft qu\u1ea3 kh\u00e1 t\u01b0\u01a1ng \u0111\u1ed3ng, trong \u0111\u00f3 th\u1ee9 t\u1ef1 li\u00ean k\u1ebft v\u1edbi 3W37:&nbsp;<strong>QN2&nbsp;<\/strong>\u02c3&nbsp;<strong>QN3&nbsp;<\/strong>\u02c3&nbsp;<strong>QN1&nbsp;<\/strong>\u02c3&nbsp;<strong>QN19&nbsp;<\/strong>\u02c3&nbsp;<strong>QN5&nbsp;<\/strong>v\u00e0 li\u00ean k\u1ebft v\u1edbi 3AJ7:&nbsp;<strong>QN5&nbsp;<\/strong>\u02c3&nbsp;<strong>QN2&nbsp;<\/strong>\u02c3&nbsp;<strong>QN3&nbsp;<\/strong>\u02c3&nbsp;<strong>QN15&nbsp;<\/strong>\u02c3&nbsp;<strong>QN1&nbsp;<\/strong>=&nbsp;<strong>QN19<\/strong>. N\u0103m quy t\u1eafc c\u1ee7a Lipinski cho th\u1ea5y ch\u1ea5t&nbsp;<strong>QN3&nbsp;<\/strong>l\u00e0 h\u1ee3p ch\u1ea5t ti\u1ec1m n\u0103ng nh\u1ea5t khi \u1ee9ng d\u1ee5ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, trong khi c\u00e1c ch\u1ea5t&nbsp;<strong>QN1<\/strong>,&nbsp;<strong>QN2&nbsp;<\/strong>v\u00e0&nbsp;<strong>QN5&nbsp;<\/strong>l\u00e0 c\u00e1c ch\u1ea5t th\u00edch h\u1ee3p nh\u1ea5t cho m\u00f4i tr\u01b0\u1eddng sinh l\u00fd c\u1ee7a c\u01a1 th\u1ec3 trong nghi\u00ean c\u1ee9u n\u00e0y. C\u00e1c k\u1ebft qu\u1ea3 thu \u0111\u00e3 cho th\u1ea5y c\u00f3 s\u1ef1 t\u01b0\u01a1ng \u0111\u1ed3ng gi\u1eefa t\u00ednh to\u00e1n l\u00fd thuy\u1ebft v\u00e0 th\u1ef1c nghi\u1ec7m, t\u01b0\u01a1ng quan c\u1ea5u tr\u00fac ho\u1ea1t t\u00ednh c\u1ee7a c\u00e1c d\u1eabn xu\u1ea5t iridoid tr\u00ean c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c protein th\u1ee7y ph\u00e2n carbohydrate 3W37 v\u00e0 3AJ7 \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.6.png\/69d70898-2fcf-492b-9394-adace28330eb?t=1657266229147\"><img decoding=\"async\" src=\"https:\/\/vast.gov.vn\/documents\/20182\/9809585\/cayquaonuoc.6.png\/69d70898-2fcf-492b-9394-adace28330eb?t=1657266229147\" alt=\"\" \/><\/a><\/figure>\n\n\n\n<p><em>Docking ph\u00e2n t\u1eed gi\u1eefa ch\u1ea5t QN3, QN5 v\u00e0 QN12 v\u1edbi protein 3W37<\/em><\/p>\n\n\n\n<p>Nh\u1eefng \u0111\u00f3ng g\u00f3p m\u1edbi c\u1ee7a \u0111\u1ec1 t\u00e0i l\u00e0:<br>&#8211;&nbsp;&nbsp; &nbsp;L\u1ea7n \u0111\u1ea7u ti\u00ean th\u00e0nh ph\u1ea7n h\u00f3a h\u1ecdc c\u1ee7a qu\u1ea3 c\u00e2y Quao n\u01b0\u1edbc \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u<br>&#8211;&nbsp;&nbsp; &nbsp;03 ch\u1ea5t l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb lo\u00e0i n\u00e0y v\u00e0 05 d\u1eabn xu\u1ea5t iridoid b\u00e1n t\u1ed5ng h\u1ee3p m\u1edbi<br>&#8211;&nbsp;&nbsp; &nbsp;L\u1ea7n \u0111\u1ea7u ti\u00ean nghi\u00ean c\u1ee9u \u0111\u00e1nh gi\u00e1 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf enzyme \u03b1- glucosidase c\u1ee7a c\u00e1c d\u1eabn xu\u1ea5t v\u00e0 c\u00e1c iridoid ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c t\u1eeb c\u00e2y Quao n\u01b0\u1edbc.<br>&#8211;&nbsp;&nbsp; &nbsp;L\u1ea7n \u0111\u1ea7u ti\u00ean nghi\u00ean c\u1ee9u t\u00ednh to\u00e1n l\u00fd thuy\u1ebft tr\u00ean m\u00f4 h\u00ecnh docking ph\u00e2n t\u1eed c\u1ee7a 15 iridoid \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ed1i t\u01b0\u01a1ng quan c\u1ea5u tr\u00fac ho\u1ea1t t\u00ednh.<\/p>\n\n\n\n<p>\u0110\u1ec1 t\u00e0i \u0111\u01b0\u1ee3c x\u1ebfp lo\u1ea1i Xu\u1ea5t s\u1eafc.<\/p>\n\n\n\n<p><em>Ngu\u1ed3n: Chu Th\u1ecb Ng\u00e2n, Trung t\u00e2m Th\u00f4ng tin &#8211; T\u01b0 li\u1ec7u<br>X\u1eed l\u00fd tin: Ph\u01b0\u01a1ng H\u00e0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>G\u00f2 Quao l\u00e0 m\u1ed9t huy\u1ec7n thu\u1ed9c t\u1ec9nh Ki\u00ean Giang.https:\/\/vi.wikipedia.org\/wiki\/G%C3%B2_Quao Theo&nbsp;L\u00ea Trung Hoa: G\u00f2 Quao l\u00e0 huy\u1ec7n c\u1ee7a t\u1ec9nh Ki\u00ean Giang, di\u1ec7n t\u00edch 424,3km2, d\u00e2n s\u1ed1134.400 ng\u01b0\u1eddi (2006), g\u1ed3m m\u1ed9t th\u1ecb tr\u1ea5n v\u00e0 10 x\u00e3. G\u00f2 Quao v\u1ed1n c\u00f3 ngh\u0129a l\u00e0 \u201cg\u00f2 c\u00f3 nhi\u1ec1u c\u00e2y quao\u201d. Quao l\u00e0 \u201cgi\u1ed1ng c\u00e2y l\u00e1 c\u00f3 ch\u1ea5t nhu\u1ed9m m\u00e0u \u0111en\u201d.* &hellip; <a href=\"https:\/\/wiki.nguoianphu.com\/diadanh\/2024\/06\/23\/go-quao\/\" class=\"more-link\">\u0110\u1ecdc ti\u1ebfp <span class=\"screen-reader-text\">G\u00f2 Quao<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[],"class_list":["post-64","post","type-post","status-publish","format-standard","hentry","category-g"],"_links":{"self":[{"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/posts\/64","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/comments?post=64"}],"version-history":[{"count":0,"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/posts\/64\/revisions"}],"wp:attachment":[{"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/media?parent=64"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/categories?post=64"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wiki.nguoianphu.com\/diadanh\/wp-json\/wp\/v2\/tags?post=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}